解剖学和形态学
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行为科学
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牙科,口腔外科和医学
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abstract::Checkpoint-blocking antibodies can generate potent anti-tumor responses by encouraging the immune system to seek and destroy cancer cells. At this time, the United States Food and Drug Administration has approved three checkpoint-blocking antibodies in three disease indications, and additional approvals are expected t...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2016.04.023
更新日期:2016-05-17 00:00:00
abstract::Inflammatory intestinal diseases are characterized by abnormal immune responses and affect distinct locations of the gastrointestinal tract. Although the role of several immune subsets in driving intestinal pathology has been studied, a system-wide approach that simultaneously interrogates all major lineages on a sing...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.04.014
更新日期:2016-05-17 00:00:00
abstract::Generally, two signals are required to activate the NLRP3 inflammasome. In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in response to a single stimulus. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.03.015
更新日期:2016-04-19 00:00:00
abstract::The participation of a specific subset of B cells and how they are regulated in cancer is unclear. Here, we demonstrate that the proportion of CD5(+) relative to interleukin-6 receptor α (IL-6Rα)-expressing B cells was greatly increased in tumors. CD5(+) B cells responded to IL-6 in the absence of IL-6Rα. IL-6 directl...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.04.003
更新日期:2016-04-19 00:00:00
abstract::Few apoptotic corpses are seen even in tissues with high cellular turnover, leading to the notion that the capacity for engulfment in vivo is vast. Whether corpse clearance can be enhanced in vivo for potential benefit is not known. In a colonic inflammation model, we noted that the expression of the phagocytic recept...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.02.005
更新日期:2016-04-19 00:00:00
abstract::Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.02.027
更新日期:2016-03-15 00:00:00
abstract::The cationic polysaccharide chitosan is an attractive candidate adjuvant capable of driving potent cell-mediated immunity, but the mechanism by which it acts is not clear. We show that chitosan promotes dendritic cell maturation by inducing type I interferons (IFNs) and enhances antigen-specific T helper 1 (Th1) respo...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.02.004
更新日期:2016-03-15 00:00:00
abstract::Phagocytes clear dying cells within an organism to prevent damaging inflammation and autoimmunity. In this issue of Immunity, Luo et al. (2016) describe how "find-me" signals from apoptotic cells induce erythropoietin signaling within macrophages to prime them for efferocytosis. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.01.023
更新日期:2016-02-16 00:00:00
abstract::Chimeric antigen receptors (CARs) redirect T cell cytotoxicity against cancer cells, providing a promising approach to cancer immunotherapy. Despite extensive clinical use, the attributes of CAR co-stimulatory domains that impact persistence and resistance to exhaustion of CAR-T cells remain largely undefined. Here, w...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.01.021
更新日期:2016-02-16 00:00:00
abstract::Lineage commitment during myelopoiesis has been linked to late-stage progenitors with multi-lineage potential. In a recent issue of Cell, Paul et al. (2015) now suggest a much earlier commitment toward distinct lineages even prior to the common myeloid progenitor state. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.12.019
更新日期:2016-01-19 00:00:00
abstract::Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when comparing various datasets. For instance, conservation of the transcriptional response to sepsis in mouse models and human disease remains controversial. To improv...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.12.006
更新日期:2016-01-19 00:00:00
abstract::Commensal microorganisms influence malignant progression by altering systemic inflammation. New data from two groups (Vétizou et al., 2015; Sivan et al., 2015) indicate that the abundance of specific commensal bacterial species enhances the anti-cancer activity of immune checkpoint inhibitors. ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.11.014
更新日期:2015-12-15 00:00:00
abstract::Phosphatidylinositol 3' OH kinase (PI3K) signaling and FOXO transcription factors play opposing roles at several B cell developmental stages. We show here abundant nuclear FOXO1 expression in the proliferative compartment of the germinal center (GC), its dark zone (DZ), and PI3K activity, downregulating FOXO1, in the ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.10.021
更新日期:2015-12-15 00:00:00
abstract::Epithelial cells orchestrate pulmonary homeostasis and pathogen defense and play a crucial role in the initiation of allergic immune responses. Maintaining the balance between homeostasis and inappropriate immune activation and associated pathology is particularly complex at mucosal sites that are exposed to billions ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.10.012
更新日期:2015-11-17 00:00:00
abstract::Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.09.008
更新日期:2015-10-20 00:00:00
abstract::Immunoglobulin A (IgA) is prominently secreted at mucosal surfaces and coats a fraction of the intestinal microbiota. However, the commensal bacteria bound by IgA are poorly characterized and the type of humoral immunity they elicit remains elusive. We used bacterial flow cytometry coupled with 16S rRNA gene sequencin...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.08.007
更新日期:2015-09-15 00:00:00
abstract::Infiltration of regulatory T (Treg) cells into many tumor types correlates with poor patient prognoses. However, mechanisms of intratumoral Treg cell function remain to be elucidated. We investigated Treg cell function in a genetically engineered mouse model of lung adenocarcinoma and found that Treg cells suppressed ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.08.006
更新日期:2015-09-15 00:00:00
abstract::What causes slow wound healing rates in diabetes is poorly understood. Wong et al. (2015) report that an increase in the deployment of neutrophil extracellular traps associated with hyperglycemia slows down wound healing. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.08.002
更新日期:2015-08-18 00:00:00
abstract::Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by specific inhibitory receptors, yet none of the known receptors are conserved in evolution. We report that within the human immune system, receptor protein tyro...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.07.009
更新日期:2015-08-18 00:00:00
abstract::When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs). Although IFN-λ stimulates expression of antiviral ISGs preferentially i...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2015.07.001
更新日期:2015-07-21 00:00:00
abstract::Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.06.011
更新日期:2015-07-21 00:00:00
abstract::Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses. However, deregulated production and/or activation of these cytokines can lead to the development of multiple inflammatory disorders. IL-1 fam...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2015.06.003
更新日期:2015-06-16 00:00:00
abstract::In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.05.002
更新日期:2015-05-19 00:00:00
abstract::Cytotoxic T lymphocytes (CTLs) use polarized secretion to rapidly destroy virally infected and tumor cells. To understand the temporal relationships between key events leading to secretion, we used high-resolution 4D imaging. CTLs approached targets with actin-rich projections at the leading edge, creating an initiall...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.04.013
更新日期:2015-05-19 00:00:00
abstract::The mechanistic links between genetic variation and autoantibody production in autoimmune disease remain obscure. Autoimmune lymphoproliferative syndrome (ALPS) is caused by inactivating mutations in FAS or FASL, with autoantibodies thought to arise through failure of FAS-mediated removal of self-reactive germinal cen...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.04.010
更新日期:2015-05-19 00:00:00
abstract::Acute lung injury (ALI) remains a serious health issue with little improvement in our understanding of the pathophysiology and therapeutic approaches. We investigated the mechanism that lipopolysaccharide (LPS) induces early neutrophil recruitment to lungs and increases pulmonary vascular permeability during ALI. Intr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.03.007
更新日期:2015-04-21 00:00:00
abstract::Regulatory B (Breg) cells are immunosuppressive cells that support immunological tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflammatory lymphocytes. R...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2015.04.005
更新日期:2015-04-21 00:00:00
abstract::Radiotherapy induces DNA damage and cell death, but recent data suggest that concomitant immune stimulation is an integral part of the therapeutic action of ionizing radiation. It is poorly understood how radiotherapy supports tumor-specific immunity. Here we report that radiotherapy induced tumor cell death and trans...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.03.009
更新日期:2015-04-21 00:00:00
abstract::Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.03.001
更新日期:2015-03-17 00:00:00
abstract::Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. We have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate inhibition of erythrocyte invasi...
journal_title:Immunity
pub_type: 临床试验,杂志文章
doi:10.1016/j.immuni.2015.02.012
更新日期:2015-03-17 00:00:00
abstract::CD4(+) T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4(+) T-cell lineages is critical for immune homeostasis and prevention of autoimmune disease. However, the factors that regulate lineage stability are largely unknown. Here we i...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.02.003
更新日期:2015-03-17 00:00:00
abstract::T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched antibodies. The differentiation of Tfh cells is a multi-step process that depends upon the co-receptor ICOS and the activation of phosphoinositide-3 kinase leading to the expression of key Tfh cell genes. We report that ICO...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.01.017
更新日期:2015-02-17 00:00:00
abstract::Reprogramming of cellular metabolism is crucial for T cells responding to environmental cues. Blagih et al. (2015) reveal that the kinase AMPK directs metabolic adaption of effector T cells upon nutrient limitation and contributes to immune responses in vivo. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2014.12.029
更新日期:2015-01-20 00:00:00
abstract::Adaptive immune responses begin when naive CD4(+) T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentiated CD4(+) T helper and T regulatory cells. Whether and how ligand-induced N...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.12.027
更新日期:2015-01-20 00:00:00
abstract::Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria monocytogenes induced the early necroptotic death of Kupffer cells, which was followed by monocyte recruitment and an anti-bacteri...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.12.020
更新日期:2015-01-20 00:00:00
abstract::The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2014.12.009
更新日期:2014-12-18 00:00:00
abstract::Diet-induced obesity can induce low-level inflammation and insulin resistance. Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined. Here we found reduced ex...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.11.013
更新日期:2014-12-18 00:00:00
abstract::CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy....
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2014.11.005
更新日期:2014-11-20 00:00:00
abstract::Interleukin-22 (IL-22) plays a critical role in mucosal defense, although the molecular mechanisms that ensure IL-22 tissue distribution remain poorly understood. We show that the CXCL16-CXCR6 chemokine-chemokine receptor axis regulated group 3 innate lymphoid cell (ILC3) diversity and function. CXCL16 was constitutiv...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.10.007
更新日期:2014-11-20 00:00:00
abstract::Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high-affinity antibodies and memory B cells. Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2014.10.004
更新日期:2014-10-16 00:00:00